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Methotrexate and tamoxifen

Authoring team

Liver toxicity

  • taking methotrexate and tamoxifen together can increase the risk of liver toxicity

Suggested management options (1):

  • routine monitoring of methotrexate should detect any signs of liver toxicity
  • an oncologist may give further advice on the use of these two medicines together

Reference:

  1. NHS Specialist Pharmacy Service (June 30th 2025). Managing interactions with methotrexate

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