This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Steroid treatment in SLE

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Prednisolone is the most common in the UK - give 0.75-1.0 mg per kg for 6-10 weeks then reduce to maintenance level. In the USA, prednisone is preferred - equipotent but with more mineralocorticoid activity.

Modern consensus is that there is no place for pulsed therapy in routine treatment because of the potential dangers, the expense and no proven benefit. Pulsed regimes such as high dose (1g) iv. methylprednisolone for 3 days should be reserved for special circumstances such as failure to respond to high dose oral steroids, or the rapid treatment of disease flares in patients already compromised by cumulative side effects.

Alternate day steroids are associated with fewer Cushingoid side effects and are of use in maintenance treatment but not in the management of acute disease flares.

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.


Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.