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Guanosine phosphate compounds

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Guanosine phosphate compounds are cellular energy intermediates. They consist of:

  • the nitrogenous base, guanine
  • the sugar ribose
  • 1-3 phosphate groups forming guanosine mono-, di- and triphosphate respectively (GMP, GDP, GTP)

Similar to the adenosine phosphate family, the energy held within the terminal phosphate bond of a given compound can be liberated in coupled reactions. The addition of inorganic phosphate groups to either GMP or GDP results in compounds of increasing energy storage. An example of such a reaction is the formation of GTP from coupling with the conversion of succinyl-CoA to succinate in the tricarboxylic acid cycle.

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