Hepatic microsomal enzyme inhibiting substances
Drugs which inhibit hepatic enzymes may have the following effects:
- they may increase the bioavailability of other drugs which are metabolised by those enzymes
- they may decrease the bioavailability of drugs which require metabolism for their activation
Examples include:
- alcohol consumed during 'binges'
- antibiotics:
- isoniazid
- erythromycin
- sulphonamides
- metronidazole
- chloramphenicol
- ketoconazol
- anticonvulsants, particularly valproate
- cimetidine
- allopurinol
- chlorpromazine
- imipramine
- propranolol
- metoprolol
- interferon
Reference:
- Adachi Y et al (1995). Potentiation of warfarin by interferon (letter). BMJ, 311, 292.
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