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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Hepatosplenomegaly is enlargement of both the spleen and liver. Causes include:

  • infection:
    • acute viral hepatitis
    • infectious mononucleosis
    • cytomegalovirus

  • haematological disease:
    • leukaemia
    • myeloproliferative disease
    • lymphoma
    • pernicious anaemia
    • sickle cell anaemia
    • thalassaemia

  • chronic liver disease and portal hypertension:
    • chronic active hepatitis

  • amyloidosis

  • acromegaly

  • systemic lupus erythematosus

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