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Propofol

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Propofol is a phenol derivative used for the induction and maintenance of intravenous general anaesthesia. It may also be used for the sedation of ventilated patients on ITU, for short procedures, or for day-case surgery.

Advantages include:

  • rapid onset
  • rapid recovery due to rapid redistribution within the body compartments - half life is about four hours - this also allows it to be used for IV maintenance instead of a volatile agent
  • less "hangover" effect

Disadvantages:

  • pain on intravenous injection
  • dose-related cardiorespiratory depression, especially in the hypovolaemic patient or the patient receiving vagotonic drugs

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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