Acute lymphoblastic leukaemia (ALL) also referred to as acute lymphocytic leukaemia, is a primary neoplasm of the bone marrow. (1,2,3)
- the malignant cells are the lymphocyte precursor cells (immature lymphoid blast cells - lymphoblasts)
- there is accumulation of lymphoblasts (in the marrow or various extramedullary sites) and also frequent suppression of normal haematopoiesis
- both B-cell and T-cell lymphoblasts may be responsible for ALL
- it is primarily a disease of children and young adults but can occur at any age
The Philadelphia chromosome (Ph1) is seen in around 20% of adults and in a small percentage children with ALL (when compared to acute myeloid leukaemia where Ph1 occurs in only 1% to 2% of patients). In Philadelphia chromosome positive ALL patients:
- usually presents with higher white blood cell and blast counts
- children and adults who are sufficiently fit and have a well-matched donor, the most appropriate therapy is myeloablative allogeneic hematopoietic stem cell transplantation (HSCT)
References:
- Alaggio R, Amador C, Anagnostopoulos I, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022 Jul;36(7):1720-48.
- National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: acute lymphoblastic leukemia [internet publication].
- Terwilliger T, Abdul-Hay M. Acute lymphoblastic leukemia: a comprehensive review and 2017 update. Blood Cancer J. 2017 Jun 30;7(6):e577.