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Acute lymphoblastic leukaemia (ALL) also referred to as acute lymphocytic leukaemia, is a primary neoplasm of the bone marrow.
The Philadelphia chromosome (Ph1) is seen in around 20% of adults and in a small percentage children with ALL (when compared to acute myeloid leukaemia where Ph1 occurs in only 1% to 2% of patients) (2). In Philadelphia chromosome positive ALL patients: