High gastrin levels
Some conditions are associated with raised gastrin levels. Examples of causes of marked elevation in gastrin levels include:
- gastrinoma
- small bowel resection
- hypochlorhydria - leads to hyperplasia of the antral gastrin secreting cells and 75% of patients with pernicious anaemia have a marked elevation in gastrin levels
Gastric ulcers may be associated with a mild elevation in gastrin levels. The gastrin level in patients with duodenal ulcers is normal but rises more than normal after a protein meal.
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