Coffee consumption and prostate cancer

Coffee consumption has been reported to be inversely associated with prostate cancer risk and progression to advanced disease and mortality (1,2,3).

How could coffee be protective?

• protective effect is biologically plausible, given coffee's abundance of compounds with anti-oxidant and anti-inflammatory effects and reported effects on insulin levels (4,5)

Reference:

• Cao S, Liu L, Yin X, et al Coffee consumption and risk of prostate cancer: a meta-analysis of prospective cohort studies. Carcinogenesis 2014;35:256-61.
• Lu Y, Zhai L, Zeng J, et al Coffee consumption and prostate cancer risk: an updated meta-analysis. Cancer Causes Control 2014;25:591-604.
• Chen X, Zhao Y, Tao Z, et al Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis .BMJ Open 2021;11:e038902. doi: 10.1136/bmjopen-2020-03890
• Bosire C, Stampfer MJ, Subar AF, et al Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control 2013;24:1527-34.
• Tunnicliffe JM, Shearer J. Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab 2008;33:1290-300.