weight gain and zyban

Last reviewed 01/2018

  • treatment with bupropion (Zyban (R)) appears to attenuate the weight gain that commonly occurs after smoking cessation

  • evidence from one placebo-controlled trial, showed that 6 weeks after smoking cessation commenced (7 weeks after starting treatment), those who had received bupropion 300 mg per day had gained less weight than those patients on placebo (around 1.5 Kg vs. 3 Kg) (1)


  • 1) Hurt RD et al (1997). A comparison of sustained-release bupropion and placebo for smoking cessation. NEJM, 337, 1195-202.