drugs causing platelet dysfunction

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Causes include:

  • aspirin:
    • irreversibly acetylates platelet cyclo-oxygenase and impairs thromboxane A2 production
    • the effects of aspirin on platelets lasts 1 week
  • non-steroidal anti-inflammatory drugs
  • dipyrimadone
  • sulphinpyrazone
  • penicillin and cephalosporins (high doses)
  • tricyclic antidepressants
  • heparin
  • dextran

Last reviewed 01/2018