multiple endocrine neoplasia type II
In the UK, about 20 cases per year of this form of MEN are diagnosed.
MEN type II is a familial predisposition to tumours of the thyroid parafollicular C cells and the adrenal medulla.
There are two variants:
The condition has been mapped to chromosome 10q11.2.
The standard screening test for MEN-II is the measurement of serum calcitonin after the administration of pentagastrin.
Last reviewed 01/2018