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Factor VIII:C deficiency

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Haemophilia A results from a congenital deficiency of factor VIII (VIII:C) coagulant activity.

It is an X-linked recessive disorder affecting 1 in 10 000 males. Heterozygous females act as carriers but may be symptomatic when lyonisation - random inactivation of one of the X chromosomes in each cell - results in preferential expression of the abnormal X chromosome. Carriers with low normal levels of factor VIII - 40-50% - may show symptoms under severe haemostatic stress e.g. after major trauma.

The condition 'breeds' true so that in families all affected members have severe disease or all have mild disease.


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