Last edited 12/2022

This is used to describe both systemic sclerosis and morphoea. The former is a multi-system disorder whilst the latter is a purely cutaneous disease. Hardening of the skin is a common feature but unlike the variants of lupus erythematosus, the two dermopathologies involved in scleroderma are different. Both primary disease processes are essentially untreatable.

Note that a review states that systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue diseases (1)