normal or raised TSH, raised free thyroid hormones

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Normal or elevated TSH in the presence of raised free thyroid hormones is a rare disorder but may be clinically important.

The causes of this pattern of abnormality are:

  • artefact - need to repeat the tests
  • interfering antibodies
  • familial dysalbuminaemic hyperthyroxinaemia
  • amiodarone therapy
  • thyroid hormone receptor mutations
  • acute psychiatric disease
  • TSH secreting pituitary tumour
  • intermittent thyroxine overdosage

Last reviewed 01/2018

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