sedation effects of some conventional antipsychotics

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Early side effects include:

  • halpoperidol: sedation +; extrapyrimidal +++; anticholinergic +

  • thioridazine: sedation ++; extrapyrimidal +; anticholinergic +++

  • chlorpromazine: sedation +++; extrapyrimidal ++; antichoinergic++

  • trifluperazine: sedation +; extrapyrimidal +++; anticholinergic +

low = +; medium = ++; high = +++

Long-term possible side effects include weight gain, tardive dyskinesia, impotence, cardiotoxicity (e.g. prolonged QT interval and ventricular arrhythmias associated with thioridazine) and galactorrhoea.

Last reviewed 01/2018

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