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Porphyria cutanea tarda may inherited (autosomal dominant) but is commonly an acquired disorder of porphyrin metabolism.
There is a deficiency in uroporphyrinogen decarboxylase (chromosome 1p34) which results in:
- bullous reaction to sunlight
- hyperpigmentation and scarring
- liver disease
Porphyria cutanea tarda usually presents in middle and old age.
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