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porphyria cutanea tarda (PCT)

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Porphyria cutanea tarda may inherited (autosomal dominant) but is commonly an acquired disorder of porphyrin metabolism.

There is a deficiency in uroporphyrinogen decarboxylase (chromosome 1p34) which results in:

  • bullous reaction to sunlight
  • hyperpigmentation and scarring
  • liver disease

Porphyria cutanea tarda usually presents in middle and old age.

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