porphyria cutanea tarda (PCT)
Last reviewed 01/2018
Porphyria cutanea tarda may inherited (autosomal dominant) but is commonly an acquired disorder of porphyrin metabolism.
There is a deficiency in uroporphyrinogen decarboxylase (chromosome 1p34) which results in:
- bullous reaction to sunlight
- hyperpigmentation and scarring
- liver disease
Porphyria cutanea tarda usually presents in middle and old age.