Last edited 05/2022 and last reviewed 06/2022

This describes a vesicular pattern of eczema affecting the skin of the hands - cheiropompholyx - and occasionally, the feet - cheiropodopompholyx. There may be a history of allergic contact dermatitis, especially to nickel. In other cases, no specific allergen can be identified but the problem may be aggravated by sweating. The majority have no history of atopy. The condition may occur secondary to fungal infection.

This may be a recurring problem. Studies report a connection between the so-called contact pompholyx and cosmetic and hygienic products (1).

Although the condition is also known as dyshidrotic eczema, no sweat gland abnormality is seen in these patients (2). A locus on chromosome 18 has been identified for a rare form of autosomal dominant pompholyx (3).

Click here for example image of pompholyx eczema