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General side effects

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The most common side effects are gastrointestinal, especially nausea. These are dose related, often mild, and usually settle with continual use.

Side effects include:

  • psychiatric - anxiety, panic attacks, nervousness - although this does not effect the outcome in depressed patients with anxiety, hypomania or mania, hallucinations, depersonalisation
  • neurological - tremor, seizures, movement disorders, serotonin syndrome
  • cardiovascular - postural hypotension
  • metabolic and endocrine - SIADH, hyponatraemia, hyperprolactinaemia
  • hepatobiliary - abnormalities of liver function tests
  • musculoskeletal - myalgia, arthralgia
  • urological - urinary retention
  • reproductive disorders - sexual dysfunction such as anorgasmia and ejaculation disorders, galactorrhoea
  • skin disorders - pruritus, rash, ecchymoses, sweating, angioedema
  • gastrointestinal - nausea, vomiting, diarrhoea, dry mouth, anorexia; increase in risk of gastrointestinal bleeding (see linked item)
  • others including dizziness, insomnia, drowsiness, fatigue, anaphylactoid reactions, aplastic anaemia, haemolytic anaemia, pancreatitis, thrombocytopaenia

Reference:

  • (1) Current Problems in Pharmacovigilance (2000), 26, 11-12.

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