This site is intended for healthcare professionals
Login | Register (NOW FREE)

Medical search

Goodpasture's syndrome

FREE subscriptions for doctors and students... click here
You have 3 open access pages.

Goodpasture's syndrome is a rare vasculitis characterised by the triad of:

  • glomerulonephritis
  • pulmonary haemorrhage
  • autoantibodies to the glomerular basement membrane (GBM) and alveolar basement membrane (1,2)
    • antibodies bind in a linear pattern to a highly specific epitope of the *3 chain of type IV collagen of alveolar and glomerular basement membranes
    • immunoglobulins are almost exclusively of the IgG subtype (with only rare reports of non-IgG class anti-GBM antibodies)
    • IgM and IgA also may be found together with IgG along the GBM in approximately 10% to 20% of cases
    • anti-GBM antibodies may be found in the circulation by indirect immunoflourescence or radioimmunoassay

Goodpasture's syndrome occurs most frequently in young men and may cause renal failure, haemoptysis with pulmonary infiltrates and dyspnoea.


  • (1) A.H. Cohen and R.J. Glassock, Anti-GBM Glomerulonephritis including Goodpasture’s disease. In: C.C. Tisher and B.M. Brenner, Editors, Renal Pathology with Clinical and Functional Correlations ((ed 2) ed.),, Lippincott, Philadelphia, PA (1994), pp. 524–553.
  • (2) Espinosa-Melendez E et al. Goodpasture’s syndrome treated with plasmapheresis. Arch Intern Med 1980;140: 542–543.


The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions Ltd®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions Ltd® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.