Thromboxanes are synthesised predominantly by platelets and act to promote:
- platelet aggregation
- bronchoconstriction in lung
The key thromboxane is A2 - TXA2 - which degrades spontaneously to the inactive TXB2.
They act as autocoid local hormones due to their short half lives, and they are excreted in the kidney.
Last reviewed 01/2018