low molecular weight heparin & unstable angina

Last reviewed 01/2018

At a dose of 100 U/kg/day low molecular weight heparin is more or equally effective as unfractionated heparin in the treatment of unstable angina.

LMWH should be combined with aspirin.


  • Fragmin during instability in coronary artery disease (FRISC) study group (1996). Low-molecular-weight heparin during instability in coronary artery disease. Lancet, 347, 561-8.
  • Cohen, M et al. (1997). A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. NEJM, 337, 447-52.