N-terminal atrial natriuretic peptide
Last reviewed 07/2021
Atrial natriuretic peptide is released by myocytes in response to atrial stretch. There are a variety of forms; the originals isolated from the brain were smaller than the forms subsequently isolated from human heart.
- reduction of ADH-induced water reabsorption in the collecting ducts
- relaxation of renal arterioles
- modulatory effects of the GFR
- inhibition of aldosterone mediated sodium reabsorption in the distal tubule (natiuretic effect)
There is massive atrial natriuretic peptide activity in end stage renal failure and congestive cardiac failure.