This site is intended for healthcare professionals
Login | Register (NOW FREE)

Medical search

Addisonian anaemia

FREE subscriptions for doctors and students... click here
You have 3 open access pages.

Pernicious anaemia (PA) is a disease of the stomach that is characterised by megaloblastic anaemia due to vitamin B12 deficiency, itself, secondary to intrinsic factor deficiency and gastric atrophy. It usually has an autoimmune basis.

PA primarily affects the elderly - most patients are over 60 years of age; less than 10% of cases are under 40 years of age; it is rare in children. Women are affected more often than men, in a ratio of 3:2.

It occurs more commonly than by chance in first degree relatives, in those with blood group A and in those with fair or prematurely grey hair and blue eyes. It may be associated with autoimmune diseases, such as Addison's disease, and also with an increased risk of gastric carcinoma.

Treatment is aimed at correcting the vitamin B12 deficiency.


The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions LtdĀ®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions LtdĀ® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.