Shy-Drager syndrome

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The Shy-Drager Syndrome is a form of multiple system atrophy in which autonomic failure - notably sexual and bladder dysfunction, postural hypotension and loss of sweating - is associated with parkinsonism.

The pathogenesis involves a disruption of the cells in the intermediolateral cell column of the spinal cord and the sympathetic ganglia. Sometimes neural destruction is more widespread, resulting in, for example, cerebellar signs.

Last reviewed 01/2018

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