cognitive behaviour therapy in chronic fatigue syndrome

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A randomised controlled trial with 12-month follow-up was undertaken at the infectious diseases department outpatient clinic in Oxford, UK. 60 consecutive patients with chronic fatigue syndrome were included in the study. Various exclusion criteria were used including if the patient was receiving psychotherapy or antidepressant drugs that reduced symptoms.

Half of the patients were allocated to medical care alone and half were allocated to cognitive behaviour therapy plus medical care. The latter group of patients exhibited improved function in comparison to the group receiving medical treatment alone.


  • Sharpe M et al (1996). Cognitive behaviour therapy for chronic fatigue syndrome: a randomised controlled trial. BMJ, 312, 22-6.

Last reviewed 01/2018