prophylactic chemotherapy against PCP

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Prophylactic chemotherapy against Pneumocystis carinii definitely delays the progression to AIDS but its effects on overall survival is unclear. When CD4 count is less than 200 cells per mm^3 or with a previous episode of Pneumocystis pneumonia (PCP) - then it is usual add co-trimozazole to the regimen as primary prophylaxis against Pneumocystic carinii infection (1)

Dapsone and nebulised pentamidine have been used by some patients. Once the CD4 count increases above 200 cells/μl prophylactic therapy may be discontinued.

Co-trimoxazole also gives effective protection against toxoplasmosis infections (1).

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Last reviewed 01/2018