prophylactic chemotherapy against PCP
Prophylactic chemotherapy against Pneumocystis carinii definitely delays the progression to AIDS but its effects on overall survival is unclear. When CD4 count is less than 200 cells per mm^3 or with a previous episode of Pneumocystis pneumonia (PCP) - then it is usual add co-trimozazole to the regimen as primary prophylaxis against Pneumocystic carinii infection (1)
Dapsone and nebulised pentamidine have been used by some patients. Once the CD4 count increases above 200 cells/μl prophylactic therapy may be discontinued.
Co-trimoxazole also gives effective protection against toxoplasmosis infections (1).
- (1) The Medical Foundation for AIDS & Sexual Health (MedFASH) 2005. HIV in primary care: an essential guide to HIV for GPs, practice nurses and other members of the primary healthcare team
Last reviewed 01/2018