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Cushing's disease

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This is the most common cause of spontaneous Cushing's syndrome and is due to excessive secretion of cortisol from hyperplastic adrenals as a result of excess pituitary ACTH secretion. It is more common in women and there is radiological or clinical evidence of pituitary enlargement in 90-95% of cases.

It is conveniently remembered by recalling that its discoverer, Harvey Cushing, was a brain surgeon.

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