corpus callosum signs

Last reviewed 01/2018

Space-occupying lesions in the corpus callosum yield a distinctive clinical picture.

Mental symptoms are prominent and typically the first to be noticed. Common features are apathy, drowsiness and defect of memory; depression and anxiety may be present. Epileptic convulsions may occur.

An expanding lesion may lead to other symptoms depending upon the tissue affected:

  • midline lesions extending laterally to the central white matter may damage the corticospinal tracts
  • anterior lesions extending into the frontal lobes may cause a unilateral or bilateral grasp reflex
  • interruption of cortical callosal fibres linking related parts of the two hemispheres may produce apraxia