St John's wort and triptans

Last reviewed 01/2018

St John's wort (SJW) interacts with triptans (sumatriptan, naratriptan, rizatriptan, zolmitriptan) and may lead to increased serotonergic effects with an increased incidence of adverse reactions.

If a patient is taking SJW and triptans it is advised that the patient stops taking SJW.


  • CEM/CMO/2000/4