St John's wort and digoxin

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St John's wort interacts with digoxin and may lead to reduced digoxin levels.

Suggested management schedule of patient already taking St John's wort:

  • check digoxin level and stop St John's wort

  • note that there may be a rise in digoxin levels on stopping St John's wort

  • it may be necessary to adjust the digoxin dose


  • CEM/CMO/2000/4

Last reviewed 01/2018