St John's wort and cyclosporin

Last reviewed 01/2018

St John's wort interacts with cyclosporin and leads to reduced cyclosporin levels.

Suggested management of patients already taking SJW preparations:

  • check cyclosporin levels and stop SJW

  • note that there may be an increase in cyclosporin levels on stopping SJW

  • it may be necessary to adjust the cyclosporin dose


  • CEM/CMO/2000/4