Last edited 04/2022 and last reviewed 04/2022

  • chronic administration of colchicine may decrease the frequency of attacks
  • palliative treatment if colchicine therapy fails

A systematic review with respect to interventions in familial Mediterranean fever showed that (1):

  • based on limited evidence, review (10 RCTs; n= 312) found three times daily colchicine may reduce number of attacks and outcomes after single dose and divided doses may not be different in children
  • for colchicine-resistant disease, anakinra and canakinumab might be effective


  • Yin X, Tian F, Wu B, Xu T. Interventions for reducing inflammation in familial Mediterranean fever. Cochrane Database of Systematic Reviews 2022, Issue 3. Art. No.: CD010893. DOI: 10.1002/14651858.CD010893.pub4