Primary tumours which give rise to metastases to bone are remembered by many students by the nonsense rule that they all begin with a B. Thus:
- byroid (thyroid)
- bidney (kidney)
- bostate (prostate)
- (rarely, bowel)
More than 66% of metastatic secondaries to bone arise from breast or prostate.
Metastases to bone usually occur in areas that contain red marrow. Metastatic deposits destroy and replace bone, partly by their own expansion and partly by stimulating active bone resorption.
Malignant melanoma may also metastasise to bone.