SSRIs and St John's wort

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St John's wort (SJW) interacts with selective serotonin reuptake inhibitors (SSRIs) and may lead to increased serotonergic effects with an increased incidence of adverse reactions.

If a patient is being prescribed an SSRI and taking SJW then it is advised that the patient stops taking SJW.


  • CEM/CMO/2000/4

Last reviewed 01/2018