pentagastrin test

Last reviewed 01/2018

The pentagastrin test is a test of basal and stimulated acid production by the parietal cells of the stomach. Pentagastrin is a synthetic peptide containing the five terminal amino acids of gastrin.

The pentagastrin test may be used in the diagnosis of:

  • Zollinger-Ellison syndrome:
    • basal acid secretion is high
    • little stimulation by pentagastrin

  • Achlorhydria:
    • basal acid secretion is low
    • little stimulation by pentagastrin