clozapine (trial in refractory schizophrenia)

FREE subscriptions for doctors and students... click here
You have 3 more open access pages.

423 hospitalised patients with refractory schizophrenia were randomised to clozapine or standard treatment with haloperidol.

57% of clozapine patients and 61% of haloperidol patients continued with the assigned drug for the whole year.

Clozapine patients had 5.4% lower symptom scores (score 79.1 vs. 83.6, P=0.02).

Clozapine patients needed fewer days of inpatient treatment (143.8 vs. 168.1, P=0.03).

Despite a higher drug bill in the clozapine group the annual total cost was less because of the fewer inpatient days.


  • Rosenheck R. et al (1997). A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. NEJM, 337, 809-15.

Last reviewed 01/2018