endocrine tests

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The triad of endocrine abnormalities consists of:

  • elevated luteinizing hormone with normal follicle stimulating hormone

  • elevated free testosterone:
    • a combination of increased testosterone production and reduced sex hormone binding globulin

  • insulin resistance with compensatory hyperinsulinaemia

Blood should be taken during the first week after menstruation.

Characteristically serum concentration of testosterone is above 2.5nmol/l and serum LH above 10 IU/l (1). A serum testosterone level of above 4.8 nmol/l requires exclusion of other causes of androgen hypersecretion such as an androgen-secreting adrenal or ovarian tumour, Cushing's syndrome or non-classical congenital adrenal hyperplasia (1).

Reference:

  • (1) Balen AH et al (1995). Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod, 10, 2107-11.

Last reviewed 05/2022

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