progressive muscular atrophy

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This is a form of motor neurone disease (MND).

Progressive muscular atrophy results from a lesion of anterior horn cells. The presentation is with asymmetrical limb wasting and weakness progressing to a condition where lower motor neurone signs predominate.

PMA accounts for 15-35% of cases of MND (1).


  • NICE (April 2006). Review decision on the use of Riluzole for the treatment of motor neurone disease.

Last reviewed 01/2018