This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Renin - angiotensin system

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Renin is a proteolytic enzyme produced by the juxtaglomerular apparatus that converts angiotensinogen in the blood to angiotensin I. Renin release is under the control of a number of factors including blood pressure and volume, and urinary composition. For example, its release is suppressed by sodium and water overload as can occur in primary hyperaldosteronism.

Angiotensin I is converted by angiotensin converting enzyme in the lung to angiotensin II. Angiotensin II then stimulates the adrenal cortex to produce aldosterone. It is also a potent peripheral vasoconstrictor. Aldosterone causes reabsorption of sodium and water from the urine in exchange for potassium and hydrogen ions by activating a pump in distal renal tubule.


Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page