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osteoporosis and HRT

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Oteoporosis and HRT

  • the baseline population risk of fragility fracture for women around menopausal age in the UK is low and varies from one woman to another

Risk of fragility fracture is decreased while taking HRT and that this benefit:

  • is maintained during treatment but decreases once treatment stops
  • may continue for longer in women who take HRT for longer.

Table: Absolute rates of any fragility fracture for HRT compared with no HRT (or placebo), different durations of HRT use and time since stopping HRT for menopausal women


    Current HRT users Treatment duration <5 years Treatment duration 5-10 years >5 years since stopping treatment
Women on any HRT RCT estimate 23 fewer (-10 to -33) 25 fewer (-9 to -37) No available data No available data
Women on any HRT Observational estimate 16 fewer (-15 to -18) 15 fewer (-11 to -17) 18 fewer (-15 to -20) 2 more (-19 to 27)



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