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Clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Acute skin reactions may develop during direct sun exposure or shortly afterwards:

  • burning, stinging and itching in sun-exposed skin:
    • especially the face and hands
    • skin lesions may be erythematous, oedematous or urticarial
    • rarely, there may be purpura or bullae on the nose and hands

Chronic skin manifestations include:

  • small, atrophic waxy scars over nose and dorsa of hands where the skin lesions have resolved
  • "aged" knuckles and fingers where the skin has thickened, wrinkled and become waxy
  • superficial scarring of the nose, face and back of the neck

Other features include:

  • haemolytic anaemia
  • splenomegaly
  • cholelithiasis
  • hepatic failure
  • increased amounts of protoporphyrin in erythrocytes, and usually, the faeces.

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