theophylline overdose

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Features:

  • vomiting
  • hypokalaemia
  • convulsions - these tend to occur after moderate / severe overdosage
  • plasma theophylline concentrations are a good guide to toxicity

Management:

  • activated charcoal and gastric lavage
  • haemoperfusion - if the patient is unable to tolerate charcoal or seriously ill patient with severe acidosis, coma or circulatory instability in addition to a very high theophylline level

Last reviewed 01/2018

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