Last reviewed 01/2023

Proton pump inhibitors (PPIs) such as omeprazole and lansoprazole inhibit the production of gastric acid.

They are the drugs of choice for patients with significant erosive oesophagitis and for patients with Zollinger- Ellinson syndrome.

The NICE guideline concerning the management of dyspepsia in primary care suggests PPIs as first-line therapies in non-ulcer dyspepsia, gastro-oesophageal reflux disease and peptic ulcer disease (see linked NICE dyspepsia guideline).