unstable trinucleotide repeats
Dynamic mutations, notably the expansion of trinucleotide repeats within the genome, have been associated with a number of clinical disorders which can be subdivided into:
- neurodegenerative diseases, such as Huntington's disease
- mental retardation, such as fragile X syndrome
Myotonic dystrophy is caused by dynamic mutations but cannot be easily assigned to either group.
Last reviewed 01/2018