thrombosis (inherited hypercoagulable states)

FREE subscriptions for doctors and students... click here
You have 3 more open access pages.

An inherited tendency to thrombosis is termed thrombophilia.

The genetic causes of many of the thrombophilias have recently been identified.

In many cases, specific prothrombotic mutations in antithrombotic factors are responsible.

There are three systems which are commonly involved in the pathogenesis of thrombophilia:

  • the antithrombin / heparin system
  • the protein C / protein S system
  • the fibrinolytic system

Last reviewed 01/2018

Links: