ANP

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Atrial natriuretic peptide is released by myocytes in response to atrial stretch. There are a variety of forms; the originals isolated from the brain were smaller than the forms subsequently isolated from human heart.

Actions:

  • reduction of ADH-induced water reabsorption in the collecting ducts
  • relaxation of renal arterioles
  • modulatory effects of the GFR
  • inhibition of aldosterone mediated sodium reabsorption in the distal tubule (natiuretic effect)

There is massive atrial natriuretic peptide activity in end stage renal failure and congestive cardiac failure.

Last reviewed 07/2021

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