slow heart rate (drug induced)

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  • drugs that depress sinus node function eg digoxin, beta blocking agents, methyldopa

  • some antiarrythmic may cause difficulties in patients predisposed to sinus node dysfunction eg disopyramide, amiodarone, verapamil, flecainide

  • uncommon causes of bradycardia or sinus arrest include lithium, cimetidine, co-dergocrine mesilate(1)


  • Shaw DB.Bradycardia, sinus node disease, sino-atrial dysfunction and heart block.Medicine International;21(11): 446-52.

Last reviewed 01/2018