Studies Of Left Ventricular Dysfunction - treatment arm

Last reviewed 01/2018

This multicentre, randomised, double-blind, placebo-controlled trial enrolled 2569 patients with reduced left ventricular function (ejection fraction <35%) and symptomatic heart failure.

The addition of enalapril to the conventional heart failure therapy was found to significantly:

  • reduce mortality by 16%
  • reduce hospitalisation for heart failure by 26%


  • SOLVD Investigators. (1991). N Engl J Med. 325, 293-302.